This hearty and flavorful casserole is a perfect dish for family dinners or gatherings. Combining the rich taste of seasoned ground beef with creamy layers and a cheesy topping, it's sure to be a crowd-pleaser. The addition of Bisquick mix creates a delightful base that holds all the delicious ingredients together.
Some ingredients in this recipe might not be staples in every household. Bisquick mix is a pre-mixed baking blend that can be found in the baking aisle of most supermarkets. Diced tomatoes with green chilies add a bit of spice and can usually be found in the canned vegetable section. Make sure to pick up taco seasoning if you don't already have it in your pantry.

Ingredients for John Wayne Casserole Recipe
Ground beef: Provides the main protein and savory flavor for the casserole.
Taco seasoning: Adds a blend of spices to the ground beef, giving it a distinct Mexican flavor.
Sour cream: Adds creaminess and a slight tang to the dish.
Mayonnaise: Contributes to the creamy texture and richness of the casserole.
Cheddar cheese: Melts beautifully on top, adding a cheesy layer.
Onion: Adds a sweet and savory flavor when cooked.
Green bell pepper: Provides a crunchy texture and a fresh, slightly sweet taste.
Diced tomatoes with green chilies: Adds moisture, acidity, and a bit of heat to the casserole.
Bisquick mix: A pre-mixed baking blend that forms the base of the casserole.
Water: Used to prepare the Bisquick mix.
Technique Tip for This Recipe
When preparing the ground beef, ensure it is cooked evenly by breaking it up into small pieces with a wooden spoon or spatula. This will help the taco seasoning distribute more uniformly, enhancing the flavor throughout the dish. Additionally, when layering the bisquick mix in the baking dish, spread it out evenly to create a consistent base for the casserole, ensuring each bite has a balanced texture.
Suggested Side Dishes
Alternative Ingredients
ground beef - Substitute with ground turkey: Ground turkey is a leaner option and has a similar texture and flavor profile.
taco seasoning - Substitute with homemade spice mix: Combine chili powder, cumin, paprika, garlic powder, onion powder, and oregano for a similar flavor without preservatives.
sour cream - Substitute with Greek yogurt: Greek yogurt provides a similar tangy flavor and creamy texture with added protein.
mayonnaise - Substitute with plain yogurt: Plain yogurt can mimic the creaminess of mayonnaise while being lower in fat and calories.
cheddar cheese - Substitute with Monterey Jack cheese: Monterey Jack melts well and has a mild flavor that complements the dish.
onion - Substitute with shallots: Shallots offer a milder and slightly sweeter flavor compared to onions.
green bell pepper - Substitute with red bell pepper: Red bell peppers are sweeter and add a vibrant color to the dish.
diced tomatoes with green chilies - Substitute with diced tomatoes and canned green chilies: Combining these two ingredients separately can achieve the same flavor profile.
bisquick mix - Substitute with homemade baking mix: Mix flour, baking powder, salt, and shortening to create a similar base for the casserole.
water - Substitute with chicken broth: Chicken broth adds more flavor to the dish compared to plain water.
Alternative Recipes Similar to This Casserole
How to Store or Freeze This Casserole
Allow the John Wayne Casserole to cool completely before storing. This helps prevent condensation, which can make the dish soggy.
For short-term storage, transfer the casserole to an airtight container. Store it in the refrigerator for up to 3-4 days.
If you plan to freeze the casserole, consider using a freezer-safe baking dish. This way, you can reheat it directly in the oven without needing to transfer it.
Wrap the entire baking dish tightly with plastic wrap, followed by a layer of aluminum foil. This double layer helps prevent freezer burn and preserves the flavors.
Label the wrapped dish with the date and contents. This will help you keep track of how long it has been stored.
For individual portions, cut the casserole into serving sizes and wrap each piece in plastic wrap. Place the wrapped pieces in a freezer-safe bag or container. This makes it easy to reheat only what you need.
When ready to reheat, if frozen, allow the casserole to thaw in the refrigerator overnight. This ensures even reheating.
Preheat your oven to 350°F (175°C). Remove any plastic wrap and cover the casserole with aluminum foil to prevent the cheese from over-browning.
Bake for 20-30 minutes, or until heated through. If reheating individual portions, microwave on high for 2-3 minutes, checking halfway through to ensure even heating.
For a crispy top, remove the foil during the last 10 minutes of baking. This will allow the cheese to become bubbly and golden.
Always check the internal temperature of the reheated casserole. It should reach at least 165°F (74°C) to ensure it is safe to eat.
How to Reheat Leftovers
Preheat your oven to 350°F (175°C). Place the leftover John Wayne Casserole in an oven-safe dish. Cover it with aluminum foil to prevent it from drying out. Bake for about 20-25 minutes, or until it is heated through and the cheese is bubbly again.
For a quicker option, use the microwave. Place a portion of the casserole on a microwave-safe plate. Cover it with a microwave-safe lid or another plate to retain moisture. Heat on medium power for 2-3 minutes, checking and stirring halfway through to ensure even heating.
If you have an air fryer, preheat it to 350°F (175°C). Place the casserole in the air fryer basket, making sure it’s in a single layer. Heat for about 5-7 minutes, checking halfway through to ensure it’s warming evenly.
For stovetop reheating, place a non-stick skillet over medium heat. Add a small amount of olive oil or butter to the pan. Place the casserole in the skillet, cover with a lid, and heat for about 10 minutes, stirring occasionally to prevent sticking and ensure even heating.
Essential Tools for This Recipe
Skillet: Used to cook and brown the ground beef.
Mixing bowl: Needed to combine the sour cream, mayonnaise, and half of the shredded cheese.
Baking dish: Used to layer the bisquick mix, beef mixture, sour cream mixture, onions, bell peppers, and tomatoes.
Oven: Preheated to 350°F (175°C) for baking the casserole.
Measuring cups: Essential for accurately measuring ingredients like sour cream, mayonnaise, cheddar cheese, and water.
Spatula: Handy for stirring and mixing ingredients in the skillet and mixing bowl.
Cheese grater: Used to shred the cheddar cheese if not using pre-shredded cheese.
Can opener: Necessary for opening the can of diced tomatoes with green chilies.
Knife: Used to chop the onion and green bell pepper.
Cutting board: Provides a safe surface for chopping the onion and green bell pepper.
How to Save Time on This Recipe
Pre-cook the beef: Cook the ground beef in advance and store it in the fridge. This will save you time when assembling the casserole.
Use pre-chopped veggies: Buy pre-chopped onions and bell peppers from the store to cut down on prep time.
Shredded cheese: Purchase pre-shredded cheddar cheese to avoid the hassle of grating it yourself.
Bisquick mix: Prepare the Bisquick mix with water ahead of time and store it in the fridge until ready to use.
One-pan cooking: Use a skillet that can go from stovetop to oven to reduce the number of dishes.
John Wayne Casserole
Ingredients
Main Ingredients
- 1 lb Ground Beef
- 1 packet Taco Seasoning
- 1 cup Sour Cream
- 1 cup Mayonnaise
- 1 cup Cheddar Cheese, shredded
- 1 cup Onion, chopped
- 1 cup Green Bell Pepper, chopped
- 1 can Diced Tomatoes with Green Chilies
- 2 cups Bisquick Mix
- 1 cup Water
Instructions
- Preheat oven to 350°F (175°C).
- In a skillet, cook ground beef until browned. Drain excess fat.
- Add taco seasoning to the beef and cook according to package instructions.
- In a mixing bowl, combine sour cream, mayonnaise, and half of the shredded cheese.
- In a baking dish, layer the Bisquick mix prepared with water, beef mixture, sour cream mixture, onions, bell peppers, and tomatoes.
- Top with the remaining shredded cheese.
- Bake for 30-35 minutes, or until the cheese is melted and bubbly.
- Let it cool for a few minutes before serving.
Nutritional Value
Keywords
Suggested Appetizers and Desserts for This Recipe
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